title: "Anticoagulation"
Anticoagulation
Key Facts
For most stable VTE (DVT/PE), DOACs are first-line unless contraindicated.
Life-threatening bleeding on warfarin is reversed with PCC + vitamin K (not FFP alone).
Overview
This article covers common ED anticoagulants, basic selection, and reversal principles.
Common agents
- DOACs: apixaban, rivaroxaban, dabigatran
- Warfarin
- Heparins: UFH, LMWH
Practical selection (high level)
- DOACs are convenient for many patients with VTE
- UFH is preferred when rapid on/off is needed (procedures, high bleeding risk, severe renal failure)
- Pregnancy: LMWH (avoid warfarin/most DOACs)
Reversal (principles)
- Treat the patient first (ABCs, haemostasis, source control)
- Use agent-specific reversal where available, plus supportive transfusion as indicated
Sources
- eTG
- CC Bible
Test Your Knowledge
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A patient on warfarin has life-threatening bleeding. Which reversal strategy is most appropriate?
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Related Topics
See also: Pulmonary Embolism, Trauma Primary Survey